APPLICATION OF AHP TOOL FOR DECISION MAKING OF CHOICE OF TECHNOLOGY FOR EXTRACTION OF ANTI-CANCER BIOACTIVE COMPOUNDS OF PLANT ORIGIN

##plugins.themes.bootstrap3.article.main##

##plugins.themes.bootstrap3.article.sidebar##

Published Jul 30, 2013
Rahi Jain Bakul Rao

Abstract

Demand for medicinal plants and their exploitation around the world has prompted international agencies like the World Health Organization (WHO) and national health departments like AYUSH to focus on their sustainable utilization.  However, lack of any decision-making methodology makes it difficult for the rural entrepreneur to setup a business.  This paper has developed a Multi-Criteria Decision Making template, using the Analytic Hierarchy Process (AHP), of ranking the best technology for extraction of nine medicinal plants which grow in Western Ghats of India. These plants have more than 20% subsidy in cultivation under NMMP and have an anticancer property.  The technologies selected for AHP were agitation/centrifugation, cold solvent extraction, reflux/soxhlet extraction, cold percolation, microwave assisted extraction, sonication and hot solvent extraction.  The ability of the tool to provide selection of the extraction technology with process flexibility like criteria selection, technology selection and criteria weightages allows its use by rural entrepreneurs, technology facilitators, rural entrepreneur proposal evaluators and policy makers.

http://dx.doi.org/10.13033/ijahp.v5i1.153

Downloads

Download data is not yet available.
Abstract 2365 | PDF Downloads 26

##plugins.themes.bootstrap3.article.details##

Keywords

Extraction Technology Selection, Medicinal Plants, Analytic Hierarchy Process, Rural Entrepreneur

References
Abed, M. H., Monavari, M., Karbasi, A., Farshchi, P., & Abedi, Z. (2011).Site selection
using analytical hierarchy process by geographical information system for sustainable
coastal tourism.IPCBEE, 15, 120–124.
Bharathi, P., Philomina, D., & Chakkaravarthi, S. (2006). Estimation of colchicine in six
different species of Gloriosa grown in vivo.Indian J. Pharm. Sci., 68(6), 806–809.
Bothiraja, C., Joshi, P. P., Dama, G. Y., & Pawar, A. P. (2011).Rapid method for
isolation of plumbagin, an alternative medicine from roots of Plumbago
zeylanica.European Journal of Integrative Medicine, 3, 39–42.
doi:10.1016/j.eujim.2011.02.008
Britto, A. J. D. A., & Sujin, R. M. (2012).HPLC analysis of vitexin and fingerprint of
Vitex negundo L. Int J Pharm Pharm Sci, 4(2), 138–141.
Chen, S., Yuchun, X., & Huizhou, L. (2007). Microwave-assisted micellar extraction and
determination of glycyrrhizic acid and liquiritin in licorice root by HPLC. Chin. J. Chem.
Eng, 15(4), 474–477.
Chitra, K., Sujatha, K., Polisetti, H., Karri, S., & Reddy, C. U. (2011). Standardization of
Coscinium fenestratum with reference to berberine by high performance thin layer
chromatography.RJPBCS, 2(2), 226–229.
Choi, M. P. K., Chan, K. K. C., Leung, H. W., & Huie, C. W. (2003). Pressurized liquid
extraction of active ingredients (ginsenosides) from medicinal plants using non-ionic
surfactant solutions.Journal of Chromatography A, 983(1-2), 153–162.
Chomnawang, M. T., Trinapakul, C., & Gritsanapan, W. (2009). In vitro antigonococcal
activity of Coscinium fenestratum stem extract. Journal of Ethnopharmacology, 122(3),
445–9.
Choochote, W., Rongsriyam, K., Pitasawat, B., Jitpakdi, A., Junkum, A., Tuetun, B., &
Chaiwong, P. (2004). Evaluation of the colchicine-like activity of Gloriosa superba –
extracted fractions for mosquito (Diptera: Culicidae). Journal of Medical Entomology,
41(4), 672–76.
Cragg, G. M., & Newman, D. J. (2005). Biodiversity: A continuing source of novel drug
leads. Pure Appl Chem, 77, 7–24.
Critical Ecosystem Partnership Fund (CEPF). (2007). Western Ghats & Sri Lanka
Biodiversity Hotspot: Western Ghats Region. Arlington, USA.
Dabaghian, M. R., Hashemi, S. H., Ebadi, T., & Maknoon, R. (2008).The best available
technology for small electroplating plants applying analytical hierarchy process.Int. J.
Environ. Sci. Tech., 5(4), 479–484.
Dalavayi, S., Kulkarni, S. M., Itikala, R. L., & Itikala, S. (2006). Determination of
withaferin–A in two Withania species by RP-HPLC Method. Indian J. Pharm. Sci.,
68(2l), 253–256.
Deevanhxay, P., Suzuki, M., Maeshibu, N., Li, H., Tanaka, K., & Hirose, S. (2009).
Simultaneous characterization of quaternary alkaloids, 8-oxoprotoberberine alkaloids,
and a steroid compound in Coscinium fenestratum by liquid chromatography hybrid ion
trap time-of-flight mass spectrometry.Journal of Pharmaceutical and Biomedical
Analysis, 50(3), 413–425.
Devi, P. U., Utsumi, H., Takata, M., & Takeda, S. (2008). Enhancement of radiation
induced cell death in chicken B lymphocytes by withaferin A. Indian J Exp Biol., 46(6),
437–442.
Elkarmi, F., & Mustafa, I. (1993).Increasing the utilization of Solar Energy Technologies
(SET) in Jordan analytic hierarchy process.Energy Policy, 21(9), 978–984.
doi:10.1016/0301-4215(93)90186-J
Eng, A. T. W., Heng, M. Y., & Ong, E. S. (2007). Evaluation of surfactant assisted
pressurized liquid extraction for the determination of glycyrrhizin and ephedrine in
medicinal plants. Analytica chimica acta, 583(2), 289–295.
doi:10.1016/j.aca.2006.09.019
Garc?a? -Ayuso, L., & Castro, M. D. L. (1999).A multivariate study of the performance of
a microwave-assisted soxhlet extractor for olive seeds.Analytica Chimica Acta, 382(3),
309–316. doi:10.1016/S0003-2670(98)00795-8
Handa, S. S., Khanuja, S. P. S., Longo, G., & Rakesh, D. D. (Eds.).(2008). Extraction
technologies for medicinal and aromatic plants.Trieste, Italy: International Centre for
Science and High Technology.
Hasan, M. R., Tetsuo, K., & Islam, S. A. (2009).Landfill demand and allocation for
municipal solid waste disposal in Dhaka city — an assessment in a GIS
environment.Journal of Civil Engineering, 37(2), 133–149.
He, J., Zhao, Z., Shi, Z., Zhao, M., Li, Y., & Chang, W. (2005).Analysis of isoflavone
daidzein in Puerariae radix with micelle-mediated extraction and preconcentration.J.
Agric. Food Chem, 53(3), 518–523. doi:10.1021/jf048545q
Hummel, J. M. M., Snoek, G. J., van Til, J. A., van Rossum, W., & Ijzermann, M. J.
(2005). A multicriteria decision analysis of augmentative treatment of upper limbs in
persons with tetraplegia.Journal of Rehabilitation Research and Development, 42(5),
635–644. Retrieved from http://www.rehab.research.va.gov/jour/05/42/5/Hummel.html
Jagetia, G. C., & Baliga, M. S. (2005). The effect of seasonal variation on the
antineoplastic activity of Alstonia scholaris R. Br. in HeLa cells.Journal of
Ethnopharmacology, 96(1-2), 37–42. doi:10.1016/j.jep.2004.07.024
Javaheri, H., Nasrabadi, T., Jafarian, M. H., Rowshan, G. R., & Khoshnam, H. (2006).
Site selection of municipal solid waste landfills using analytical hierarchy process
method in a geographical information technology environment in giroft. Iran. J. Environ.
Health. Sci. Eng., 3(3), 177–184.
Jayaprakasam, B., & Nair, M. G. (2003). Cyclooxygenase-2 enzyme inhibitory
withanolides from Withania somnifera leaves. Tetrahedron, 59(6), 841–849.
doi:10.1016/S0040-4020(02)01601-0
Jeyachandran, R., Mahesh, A., Cindrella, L., Sudhakar, S., & Pazhanichamy, K. (2009).
Antibacterial activity of plumbagin and root extracts of Plumbago zeylanica L. Acta
Biologica Cracoviensia Series Botanica, 51(1), 17–22.
Jung, H. (2011). A fuzzy AHP–GP approach for integrated production-planning
considering manufacturing partners.Expert Systems with Applications, 38(5), 5833–5840.
doi:10.1016/j.eswa.2010.11.039
Jyothi D Khanam S Sultana R. (2010). Optimization of microwave assited solvent
extraction of withanolides from leaves of Ashwagandha.Pharmacie Globale (IJCP),
01(04), 1–5.
Jyothi, D., Khanam, S., & Sultana, R. (2010). Optimization of microwave assisted
extraction of withanolides from roots of Aswagandha and its comparison with
conventional extraction method. Int J Pharm Pharm Sci, 2(4), 46–50.
Kablan, M. (2004). Decision support for energy conservation promotion: an analytic
hierarchy process approach. Energy Policy, 32(10), 1151–1158. doi:10.1016/S0301-
4215(03)00078-8
Kadota, S., Takamori, Y., Nyein, K. N., Kikuchi, T., Tanaka, K., & Ekimoto, H.
(1990).Constitutents of the leaves of Woodfordia fructicosa Kurz. I. Isolation, structure,
and proton and carbon-13 nuclear magnetic signal assignments of woodfruticosin
(Woodfordin C), an inhibitor of deoxyribonucleic acid topoisomerase II. Chem. Pharm.
Bull., 38(10), 2687–97.
Kannan, S., Wesley, S. D., Ruba, A., Rajalakshmi, A. R., & Kumaragurubaran, K.
(2007).Optimization of solvents for effective isolation of colchicines from Gloriosa
superba L. seeds.Natural product research: Formerly Natural Product Letters, 21(5),
469–472. doi:10.1080/14786410601129507
Kavina, J., Gopi, R., & Panneerselvam, R. (2011). Quantification of colchicine in seed
and tuber samples of Gloriosa superba by High Performance Liquid Chromatography
method. Journal of Applied Pharmaceutical Sciences, 01(07), 116–119.
Kholkute, S. D. (2008). Coordinating unit of survey of medicinal plants of western ghats
of India. New Delhi: Indian Council of Medical Research.
Kodali, R., & Chandra, S. (2001). Analytical hierarchy process for justification of total
productive maintenance.Production Planning & Control, 12(7), 695–705.
doi:10.1080/0953728001002404
Lee, S. J., Cho, S. A., An, S. S., Na, Y. J., Park, N. H., Kim, H. S., Lee, C. W., et al.
(2012). Alstonia scholaris R. Br. significantly inhibits retinoid-induced skin irritation in
vitro and in vivo. Evidence-based complementary and alternative medicine,
2012(190370), 11. doi:10.1155/2012/190370
Lin, T., Nonaka, G., Nishioka, I., & Ho, F. (1990).Tannins and related compounds. CII.
Structures of terchebulin, an ellagitannin having a novel tetraphenylcarboxylic acid
(Terchebulic Acid) moiety, and biogenetically related tannins from Terminalia chebula
Retz. Chem. Pharm. Bull., 38(11), 3004–8.
Luque-Garc??a, J. L., & Castro, M. D. L. (2004). Ultrasound-assisted soxhlet extraction:
an expeditive approach for solid sample treatment application to the extraction of total fat
from oleaginous seeds. Journal of Chromatography A, 1034(1-2), 237–242.
doi:10.1016/j.chroma.2004.02.020
Macabeo, A. P. G., Krohn, K., Gehle, D., Read, R. W., Brophy, J. J., Cordell, G. A.,
Franzblau, S. G., et al. (2005). Indole alkaloids from the leaves of Philippine Alstonia
scholaris.Phytochemistry, 66(10), 1158–62. doi:10.1016/j.phytochem.2005.02.018
Mahajan, S., Ramakrishnan, G., & Date, A. W. (2008).User friendly package for ranking
of technology alternatives using analytical hierarchy process. Mumbai, India.
Malhotra, S., Taneja, S. C., & Dhar, K. L. (1989).Minor alkaloid from Coscinium
fenestratum.Phytochemistry, 28(7), 1998–1999.
Malik, F., Singh, J., Khajuria, A., Suri, K. A., Satti, N. K., Singh, S., Kaul, M. K., et al.
(2007). A standardized root extract of Withania somnifera and its major constituent
withanolide-A elicit humoral and cell-mediated immune responses by up regulation. Life
Sciences, 80(16), 1525–1538. doi:10.1016/j.lfs.2007.01.029
Mirzajani, F., Ghassempour, A., Jalali-Heravi, M., & Mirjalili, M.H. (2010).
Optimisation of a microwave assisted method for extracting withaferin A from
Withania somnifera Dunal. using central composite design. Phytochem. Anal.,
21(6), 544–549. Retrieved from http://onlinelibrary.wiley.com/doi/10.1002/pca.1230/full
Mohajeri, N., & Amin, G. R. (2010).Railway station site selection using analytical
hierarchy process and data envelopment analysis.Computers & Industrial Engineering,
59(1), 107–114. doi:10.1016/j.cie.2010.03.006
Montevechi, J. A. B., Guimaraes, I. F., Oliveira, M. L. M. D., & Friend, J. D.
(2010).Decision-making with multiple criteria in the selection of ultrasound scavenging
system in a private hospital in Brazil.International Journal of the Analytic Hierarchy
Process, 2(1), 14–29.
Moulisha, B., Kumar, G. A., & Kanti, H. P. (2010). Anti-leishmanial and anti-cancer
activities of a pentacyclic triterpenoid isolated from the leaves of Terminalia
arjunacombretaceae. Tropical Journal of Pharmaceutical Research, 9(2), 135–140.
Retrieved from http://www.ajol.info/index.php/tjpr/article/view/53700
National Medicinal Plants Board. (2008). Centrally sponsored scheme of National
Mission on Medicinal Plants: Operational guidelines (pp. 1–37). New Delhi, India:
AYUSH. Retrieved from:
http://nmpb.nic.in/WriteReadData/links/1734335889english1.pdf
Nijkamp, P., & Delft, A. Van. (1977). Multi-criteria analysis and regional decisionmaking.
Leiden: Martunus Nijhoff Social Sciences Division.
Nixon, J. D., Dey, P. K., & Davies, P. A. (2010). Which is the best solar thermal
collection technology for electricity generation in north-west India? Evaluation of options
using the analytical hierarchy process.Energy, 35(12), 5230–5240.
doi:10.1016/j.energy.2010.07.042
Palcic, I., & Lalic, B. (2009).Analytical hierarchy process as a tool for selecting and
evaluating projects.Int J Simul Model, 8(1), 16–26. doi:10.2507/IJSIMM08(1)2.112
Pawar, R. K., Shivani, S., Singh, K. C., & Sharma, R. K. (2010). HPTLC method for the
determination of plumbagin from Plumbago zeylanica Linn. (root). Int. J Pharm Pharm
Sci, 2(4), 219–223.
Pawar, R. S., & Bhutani, K. K. (2005). Effect of oleanane triterpenoids from Terminalia
arjuna—a cardioprotective drug on the process of respiratory oxyburst. Phytomedicine,
12(5), 391–393.
Pinho, P. M. M., Pinto, M. M. M., Kijjoa, A., Pharada, K., Diaz, J. G., & Herz, W.
(1992).Protoberberine alkaloids from Coscinium fenestratum.Phytochemistry, 31(4),
1403–1407.
Rajasekharan, P. E. (2006). Potential of plant derived pharmaceuticals. Science Tech
Entrepreneur, (April), 1–8.
Raju, U. S., Rangaraj, N., & Date, A. W. (1995).The Influence of Development
Perspectives on the Choice of Technology.Technological Forecasting and Social
Change, 43, 27–43.
Razmi, J., Rahnejat, H., & Khan, M. K. (2005).Use of analytic hierarchy process
approach in classification of push, pull and hybrid push, pull systems for production
planning.International Journal of OPerations & Production Management, 18(11), 1134–
1151.
Rojsanga, P., & Gritsanapan, W. (2005).Variation of berberine content in Coscinium
fenestratum stem in Thailand market.Mahidol University Journal of Pharmaceutical
Sciences, 32(3-4), 66–70. Retrieved from:
http://www.pharmacy.mahidol.ac.th/mujournal/_files/2005.66-70.pdf
Rojsanga, P., Gritsanapan, W., & Suntornsuk, L. (2006). Determination of Berberine
content in the stem extracts of Coscinium fenestratum by TLC densitometry. Med.
Princ.Pract., 10400, 373–378. doi:10.1159/000094272
Saaty, T. L. (1980). The Analytic Hierarchy Process. New York, USA: McGraw-Hill.
Saxena, M., Faridi, U., Mishra, R., Gupta, M. M., Darokar, M. P., Srivastava, S. K.,
Singh, D., et al. (2007). Cytotoxic agents from Terminalia arjuna. Planta medica, 73(14),
1486–1490.doi:10.1055/s-2007-990258
Singh, D. V., Verma, R. K., Singh, S. C., & Gupta, M. M. (2002). RP-LC determination
of oleane derivatives in Terminalia arjuna. J. Pharm. Biomed. Anal., 28(3-4), 447–452.
Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12008123
Singh, S., Dolan, J. G., & Centor, R. M. (2006).Optimal management of adults with
pharyngitis--a multi-criteria decision analysis.BMC medical informatics and decision
making, 6, 14.doi:10.1186/1472-6947-6-14
Skibniewski, M. J., & Chao, L. (1992).Evaluation of advanced construction technology
with AHP method.Journal of Construction Engineering and Management, 118(3), 577–
593.
Sloane, E. B., Liberatore, M. J., Nydick, R. L., Luo, W., & Chung, Q. B. (2003).Using
the analytic hierarchy process as a clinical engineering tool to facilitate an iterative,
multidisciplinary, microeconomic health technology assessment. Computers &
Operations Research, 30(10), 1447–1465. doi:10.1016/S0305-0548(02)00187-9
Stenhouse, J. (1867). XVI.-On the preparation of berberine from Coscinium fenestratum.
J. Chem. Soc., 20, 187–188. Retrieved from:
http://pubs.rsc.org/en/content/articlepdf/1867/js/js8672000187
Thampi, A., & Rao, B. (2012). Development of a decision making tool for choice of
technology in municipal solid waste management for Local Self Government Bodies - A
case study of Kerala , India. 27th International Conference on Solid Waste Technology
and Management.
Tran, L. Q., Tezuka, Y., Ueda, J., Trung, N., Maruyama, Y., Begum, K., Kim, H., et al.
(2003). In vitro antiplasmodial activity of antimalarial medicinal plants used in
Vietnamese traditional medicine. Journal of Ethnopharmacology, 86(2-3), 249–252.
doi:10.1016/S0378-8741(03)00045-X
Tungpradit, R., Sinchaikul, S., Phutrakul, S., Wongkham, W., & Chen, S. T.
(2011).Antiproliferative activity of berberine from Coscinium fenestratum on NCI-H838
cell line. Chiang Mai J. Sci., 38(1), 85–94. Retrieved from:
http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Antiproliferative+Acti
vity+of+Berberine+from+Coscinium+fenestratum+on+NCI-H838+Cell+Line#0
Unnikrishnan, K. P., Raja, S. S., & Balachandran, I. (2008).A reverse phase HPLC-UV
and HPTLC methods for determination of plumbagin in Plumbago indica and Plumbago
zeylanica.Indian J. Pharm. Sci., 70(6), 844–847. Retrieved from:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040894/
Upadhyay, R. K., Pandey, M. B., Jha, R. N., Singh, V. P., & Pandey, V. B. (2001). Triterpene
glycoside from Terminalia arjuna. Journal of Asian Natural Products Research,
3(3), 207–212. Retrieved from:
http://www.tandfonline.com/doi/abs/10.1080/10286020108041392
Ved, D. K., & Goraya, G. S. (2008). Demand and Supply of Medicinal Plants in India.
Dehradun: Bishen Singh Mahendra Pal Singh Publishers, Dehradun and FRLHT,
Bengaluru.
Venukumar, M. R. (2004). Effect of Coscinium fenestratum and Curculigo orchioides in
rat model of hepatotoxicity.Mahatma Ghandhi University.
World Health Organization.(2000). Report of the inter-regional workshop on intellectual
property rights in the context of traditional medicine. Bangkok, 6-8 Dec 2000.
World Health Organization (WHO). (2008). The global burden of disease 2004 Update.
Geneva, Switzerland.
World Health Organization (WHO).(2011). Global status report on noncommunicable
diseases 2010. Geneva, Switzerland.
Xiang, L., Jianzhong, M., Jing, X., & Yundong, S. (2011). Surfactant assisted ethanol
extraction of dioscin. Journal of Medicinal Plants Research, 5(3), 324–331. Retrieved
from http://www.academicjournals.org/jmpr/PDF/pdf2011/4Feb/Xiang et al.pdf
Yahaya, S., Ilori, C., Whanda, J. S., & Edicha, J. (2010). Land fill site selection for
municipal solid waste mangement using Geographic Information System and
Multicriteria Evaluation. American Journal of Scientific Research, 10(10), 34–49.
Yibchok-anun, S., Jittaprasatsin, W., Somtir, D., Bunlunara, W., & Adisakwattana, S.
(2009).Insulin secreting and ? -glucosidase inhibitory activity of Coscinium fenestratum
and postprandial hyperglycemia in normal and diabetic rats.Journal of Medicinal Plants
Research, 3(9), 646–651.
Zhou, H., He, H., Luo, X., Wang, Y., Yang, X., & Di, Y. (2005).Three wew indole
alkaloids from the leaves of Alstonia scholaris.Helvetica Chimca Acta, 88(9), 2508–2512.
Zhou, Y. J., Liu, Y. E., Cao, J. G., Zeng, G. Y., Shen, C., Li, Y. L., Zhou, M. C., et al.
(2009). Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor
growth. Clin Cancer Res, 15(16), 5161–5169. doi:10.1158/1078-0432.CCR-09-0661
Section
Articles